Antioxidant protection in a new animal model of cisplatin-induced ototoxicity
SB Minami, SH Sha, J Schacht - Hearing research, 2004 - Elsevier
Mortality is a major complication in animal models of cisplatin-induced hearing loss due to
the systemic toxicity of the drug. Here we report on a novel two-cycle treatment in rats, each
cycle consisting of four days of cisplatin injections (1 mg/kg, ip, twice daily) separated by 10
days of rest. This regimen, similar to clinical courses of cancer chemotherapy, produced
significant hearing loss without mortality. Auditory brain stem evoked responses were
unchanged after the first cycle but were elevated by 40–50 dB at 16 and 20 kHz after the …
the systemic toxicity of the drug. Here we report on a novel two-cycle treatment in rats, each
cycle consisting of four days of cisplatin injections (1 mg/kg, ip, twice daily) separated by 10
days of rest. This regimen, similar to clinical courses of cancer chemotherapy, produced
significant hearing loss without mortality. Auditory brain stem evoked responses were
unchanged after the first cycle but were elevated by 40–50 dB at 16 and 20 kHz after the …