Uterine eosinophils and reproductive performance in interleukin 5-deficient mice
SA Robertson, VJ Mau, IG Young… - … of Reproduction and …, 2000 - rep.bioscientifica.com
SA Robertson, VJ Mau, IG Young, KI Matthaei
Journal of Reproduction and Fertility, 2000•rep.bioscientifica.comInterleukin-5 (IL-5) is a homodimeric cytokine originally recognized for its capacity to
stimulate the growth of B cells (Kinashi et al., 1986), the secretion of immunoglobulin A
(IgA)(Yokota et al., 1987), and the differentiation, recruitment and activation of eosinophils
(Campbell et al., 1988; Sanderson et al., 1988). A high affinity, heterodimeric receptor
complex comprised of an IL-5-specific α-subunit and a signal-transducing β-subunit, shared
by the granulocyte–macrophage colony-stimulating factor (GM-CSF) and IL-3 receptors …
stimulate the growth of B cells (Kinashi et al., 1986), the secretion of immunoglobulin A
(IgA)(Yokota et al., 1987), and the differentiation, recruitment and activation of eosinophils
(Campbell et al., 1988; Sanderson et al., 1988). A high affinity, heterodimeric receptor
complex comprised of an IL-5-specific α-subunit and a signal-transducing β-subunit, shared
by the granulocyte–macrophage colony-stimulating factor (GM-CSF) and IL-3 receptors …
Interleukin-5 (IL-5) is a homodimeric cytokine originally recognized for its capacity to stimulate the growth of B cells (Kinashi et al., 1986), the secretion of immunoglobulin A (IgA)(Yokota et al., 1987), and the differentiation, recruitment and activation of eosinophils (Campbell et al., 1988; Sanderson et al., 1988). A high affinity, heterodimeric receptor complex comprised of an IL-5-specific α-subunit and a signal-transducing β-subunit, shared by the granulocyte–macrophage colony-stimulating factor (GM-CSF) and IL-3 receptors, mediates the effects of IL-5 at the target cell surface
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