PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics
JL Perry, KG Reuter, MP Kai, KP Herlihy, SW Jones… - Nano …, 2012 - ACS Publications
JL Perry, KG Reuter, MP Kai, KP Herlihy, SW Jones, JC Luft, M Napier, JE Bear…
Nano letters, 2012•ACS PublicationsIn this account, we varied PEGylation density on the surface of hydrogel PRINT
nanoparticles and systematically observed the effects on protein adsorption, macrophage
uptake, and circulation time. Interestingly, the density of PEGylation necessary to promote a
long-circulating particle was dramatically less than what has been previously reported.
Overall, our methodology provides a rapid screening technique to predict particle behavior
in vivo and our results deliver further insight to what PEG density is necessary to facilitate …
nanoparticles and systematically observed the effects on protein adsorption, macrophage
uptake, and circulation time. Interestingly, the density of PEGylation necessary to promote a
long-circulating particle was dramatically less than what has been previously reported.
Overall, our methodology provides a rapid screening technique to predict particle behavior
in vivo and our results deliver further insight to what PEG density is necessary to facilitate …
In this account, we varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed the effects on protein adsorption, macrophage uptake, and circulation time. Interestingly, the density of PEGylation necessary to promote a long-circulating particle was dramatically less than what has been previously reported. Overall, our methodology provides a rapid screening technique to predict particle behavior in vivo and our results deliver further insight to what PEG density is necessary to facilitate long-circulation.
ACS Publications