[HTML][HTML] Transgenic mouse models of Alzheimer's disease
C Janus, MA Chishti, D Westaway - … Acta (BBA)-Molecular Basis of Disease, 2000 - Elsevier
C Janus, MA Chishti, D Westaway
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 2000•Elsevier2. Objectives In this review we first provide an overview of the transgenic mice proposed to
recapitulate facets of the AD clinical phenotype, with a brief description of molecular
parameters and behavioral performance. Many such lines have now been created and to
stratify these AD models, we base our discussions upon five expectations listed below
(although some of these might seem so self-evident as to be prosaic, in fact most research
conducted thus far falls short of these notional guidelines). Our proposed expectations for a …
recapitulate facets of the AD clinical phenotype, with a brief description of molecular
parameters and behavioral performance. Many such lines have now been created and to
stratify these AD models, we base our discussions upon five expectations listed below
(although some of these might seem so self-evident as to be prosaic, in fact most research
conducted thus far falls short of these notional guidelines). Our proposed expectations for a …
2. Objectives
In this review we first provide an overview of the transgenic mice proposed to recapitulate facets of the AD clinical phenotype, with a brief description of molecular parameters and behavioral performance. Many such lines have now been created and to stratify these AD models, we base our discussions upon five expectations listed below (although some of these might seem so self-evident as to be prosaic, in fact most research conducted thus far falls short of these notional guidelines). Our proposed expectations for a credible model of AD are:
Elsevier