[HTML][HTML] Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
Many proteins suspected of causing neurodegenerative diseases exist in diverse assembly
states. For most, it is unclear whether shifts from one state to another would be helpful or
harmful. We used mutagenesis to change the assembly state of Alzheimer disease (AD)-
associated amyloid-β (Aβ) peptides. In vitro, the" Arctic" mutation (AβE22G) accelerated Aβ
fibrillization but decreased the abundance of nonfibrillar Aβ assemblies, compared with wild-
type Aβ. In human amyloid precursor protein (hAPP) transgenic mice carrying mutations …
states. For most, it is unclear whether shifts from one state to another would be helpful or
harmful. We used mutagenesis to change the assembly state of Alzheimer disease (AD)-
associated amyloid-β (Aβ) peptides. In vitro, the" Arctic" mutation (AβE22G) accelerated Aβ
fibrillization but decreased the abundance of nonfibrillar Aβ assemblies, compared with wild-
type Aβ. In human amyloid precursor protein (hAPP) transgenic mice carrying mutations …