Understanding the immune response in the central nervous system (CNS) is crucial for the
development of new therapeutic concepts in chronic neuroinflammation, which differs
considerably from other autoimmune diseases. Special immunologic properties of
inflammatory processes in the CNS, which is often referred to as an immune privileged site,
imply distinct features of CNS autoimmune disease in terms of disease initiation,
perpetuation, and therapeutic accessibility. Furthermore, the CNS is a stress‐sensitive organ …