Down-regulation of micro-RNA-1 (miR-1) in lung cancer: suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced …
MW Nasser, J Datta, G Nuovo, H Kutay… - Journal of biological …, 2008 - ASBMB
Micro-RNAs are∼ 21–25-nucleotide-long noncoding RNAs that regulate gene expression
primarily at the post-transcriptional level in animals. Here, we report that micro-RNA-1 (miR-
1), abundant in the cardiac and smooth muscles, is expressed in the lung and is down-
regulated in human primary lung cancer tissues and cell lines. In situ hybridization
demonstrated localization of miR-1 in bronchial epithelial cells. The tumor suppressor
C/EBPα, frequently suppressed in lung cancer, reactivated miR-1 expression in the lung …
primarily at the post-transcriptional level in animals. Here, we report that micro-RNA-1 (miR-
1), abundant in the cardiac and smooth muscles, is expressed in the lung and is down-
regulated in human primary lung cancer tissues and cell lines. In situ hybridization
demonstrated localization of miR-1 in bronchial epithelial cells. The tumor suppressor
C/EBPα, frequently suppressed in lung cancer, reactivated miR-1 expression in the lung …
