[HTML][HTML] The RNA-binding protein IMP-3 is a translational activator of insulin-like growth factor II leader-3 mRNA during proliferation of human K562 leukemia cells
B Liao, Y Hu, DJ Herrick, G Brewer - Journal of Biological Chemistry, 2005 - ASBMB
IMP-3, a member of the insulin-like growth factor-II (IGF-II) mRNA-binding protein (IMP)
family, is expressed mainly during embryonic development and in some tumors. Thus, IMP-3
is considered to be an oncofetal protein. The functional significance of IMP-3 is not clear. To
identify the functions of IMP-3 in target gene expression and cell proliferation, RNA
interference was employed to knock down IMP-3 expression. Using human K562 leukemia
cells as a model, we show that IMP-3 protein associates with IGF-II leader-3 and leader-4 …
family, is expressed mainly during embryonic development and in some tumors. Thus, IMP-3
is considered to be an oncofetal protein. The functional significance of IMP-3 is not clear. To
identify the functions of IMP-3 in target gene expression and cell proliferation, RNA
interference was employed to knock down IMP-3 expression. Using human K562 leukemia
cells as a model, we show that IMP-3 protein associates with IGF-II leader-3 and leader-4 …