[HTML][HTML] Neogenin interacts with matriptase-2 to facilitate hemojuvelin cleavage
CA Enns, R Ahmed, AS Zhang - Journal of Biological Chemistry, 2012 - ASBMB
Hemojuvelin (HJV) and matriptase-2 (MT2) are co-expressed in hepatocytes, and both are
essential for systemic iron homeostasis. HJV is a glycosylphosphatidylinositol-linked
membrane protein that acts as a co-receptor for bone morphogenetic proteins to induce
hepcidin expression. MT2 regulates the levels of membrane-bound HJV in hepatocytes by
binding to and cleaving HJV into an inactive soluble form that is released from cells. HJV
also interacts with neogenin, a ubiquitously expressed transmembrane protein with multiple …
essential for systemic iron homeostasis. HJV is a glycosylphosphatidylinositol-linked
membrane protein that acts as a co-receptor for bone morphogenetic proteins to induce
hepcidin expression. MT2 regulates the levels of membrane-bound HJV in hepatocytes by
binding to and cleaving HJV into an inactive soluble form that is released from cells. HJV
also interacts with neogenin, a ubiquitously expressed transmembrane protein with multiple …