[HTML][HTML] Inhibition of platelet-derived growth factor-induced cell growth signaling by a short interfering RNA for EWS-Fli1 via down-regulation of phospholipase D2 in …
S Nozawa, T Ohno, Y Banno, T Dohjima… - Journal of Biological …, 2005 - ASBMB
EWS-Fli1, a fusion gene resulting from a chromosomal translocation t (11; 22, q24; q12) and
found in Ewing sarcoma and primitive neuroectodermal tumors, encodes a transcriptional
activator and promotes cellular transformation. However, the precise biological functions of
its products remain unknown. To investigate the role of EWS-Fli1 in cell growth signaling, we
transfected Ewing sarcoma TC-135 cells with short interfering RNAs for EWS-Fli1. EWS-Fli1
knockdown reduced cell growth and platelet-derived growth factor (PDGF)-BB-induced …
found in Ewing sarcoma and primitive neuroectodermal tumors, encodes a transcriptional
activator and promotes cellular transformation. However, the precise biological functions of
its products remain unknown. To investigate the role of EWS-Fli1 in cell growth signaling, we
transfected Ewing sarcoma TC-135 cells with short interfering RNAs for EWS-Fli1. EWS-Fli1
knockdown reduced cell growth and platelet-derived growth factor (PDGF)-BB-induced …