Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation
Q Wang, AC McPherron - The Journal of physiology, 2012 - Wiley Online Library
Q Wang, AC McPherron
The Journal of physiology, 2012•Wiley Online LibraryKey points• There is disagreement about whether muscle hypertrophy requires the activation
and fusion of satellite cells, the quiescent muscle stem cells, to the multinucleated post‐
mitotic muscle fibre.• Although the growth factor myostatin is clearly a negative regulator of
muscle size, previous studies regarding its role in maintaining satellite cell quiescence have
yielded conflicting results.• We injected mice with a myostatin inhibitor and the DNA labelling
agent bromodeoxyuridine to label proliferating cells and found that a small number of …
and fusion of satellite cells, the quiescent muscle stem cells, to the multinucleated post‐
mitotic muscle fibre.• Although the growth factor myostatin is clearly a negative regulator of
muscle size, previous studies regarding its role in maintaining satellite cell quiescence have
yielded conflicting results.• We injected mice with a myostatin inhibitor and the DNA labelling
agent bromodeoxyuridine to label proliferating cells and found that a small number of …
Key points
- • There is disagreement about whether muscle hypertrophy requires the activation and fusion of satellite cells, the quiescent muscle stem cells, to the multinucleated post‐mitotic muscle fibre.
- • Although the growth factor myostatin is clearly a negative regulator of muscle size, previous studies regarding its role in maintaining satellite cell quiescence have yielded conflicting results.
- • We injected mice with a myostatin inhibitor and the DNA labelling agent bromodeoxyuridine to label proliferating cells and found that a small number of satellite cells are activated after the onset of hypertrophy.
- • We also found that myostatin null mice are not resistant to age‐related muscle mass or satellite cell loss.
- • Our results suggest that myostatin inhibition in adult mice causes hypertrophy mainly by acting on myofibres rather than satellite cells, which results in an increase in the cytoplasmic volume to DNA ratio.
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