The liver-specific microRNA miR-122: biology and therapeutic potential
W Filipowicz, H Großhans - Epigenetics and Disease: Pharmaceutical …, 2011 - Springer
W Filipowicz, H Großhans
Epigenetics and Disease: Pharmaceutical Opportunities, 2011•SpringerMicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of a large
fraction of genes in animals, plants, and protozoa. miRNA-mediated gene repression occurs
posttranscriptionally, generally by base-pairing to the 3′-untranslated regions of target
mRNAs, which inhibits protein synthesis and destabilizes the mRNA. In this chapter, we
discuss the biological functions of miR-122, a highly abundant, liver-specific miRNA. We will
review how studies of miR-122 helped to establish important new paradigms of miRNA …
fraction of genes in animals, plants, and protozoa. miRNA-mediated gene repression occurs
posttranscriptionally, generally by base-pairing to the 3′-untranslated regions of target
mRNAs, which inhibits protein synthesis and destabilizes the mRNA. In this chapter, we
discuss the biological functions of miR-122, a highly abundant, liver-specific miRNA. We will
review how studies of miR-122 helped to establish important new paradigms of miRNA …
Abstract
MicroRNAs (miRNAs) are small noncoding RNAs that regulate the expression of a large fraction of genes in animals, plants, and protozoa. miRNA-mediated gene repression occurs posttranscriptionally, generally by base-pairing to the 3′-untranslated regions of target mRNAs, which inhibits protein synthesis and destabilizes the mRNA. In this chapter, we discuss the biological functions of miR-122, a highly abundant, liver-specific miRNA. We will review how studies of miR-122 helped to establish important new paradigms of miRNA-mediated regulation, as well as identifying miR-122 as a factor implicated in important human diseases, including cancer and hepatitis C. We discuss antisense strategies targeting miR-122 as a potential therapeutic approach to treat hepatitis C and possibly other diseases.
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