[HTML][HTML] Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth
Y Zorina, R Iyengar, KD Bromberg - Journal of Biological Chemistry, 2010 - ASBMB
Activation of the G o/i-coupled cannabinoid 1 receptor (CB1R) has been shown to induce
neurite outgrowth in Neuro2A cells through activation of Src kinase and STAT3 transcription
factor. Signaling by the interleukin 6 receptor (IL-6R) also activates STAT3 through Jak
kinase. We studied if signals from the two pathways could be integrated in a synergistic
manner to trigger neurite outgrowth in Neuro2A cells. At low concentrations, when agonist at
either receptor by itself has no effect, we found that CB1R and IL-6R stimulation together …
neurite outgrowth in Neuro2A cells through activation of Src kinase and STAT3 transcription
factor. Signaling by the interleukin 6 receptor (IL-6R) also activates STAT3 through Jak
kinase. We studied if signals from the two pathways could be integrated in a synergistic
manner to trigger neurite outgrowth in Neuro2A cells. At low concentrations, when agonist at
either receptor by itself has no effect, we found that CB1R and IL-6R stimulation together …
