Interleukin-6 and prostate cancer progression
PC Smith, A Hobisch, DL Lin, Z Culig… - Cytokine & growth factor …, 2001 - Elsevier
Prostate cancer, while initially dependent on androgens for proliferation, progresses to an
androgen-independent state. Evidence has been accumulating that interleukin-6 (IL-6) may
contribute to prostate cancer progression. Serum levels of IL-6 correlate with prostate tumor
burden and patient morbidity. The prostate tissue itself appears to be a source of IL-6 and its
receptor. Furthermore, experimental data suggest that IL-6 is an autocrine and paracrine
growth factor for androgen-independent prostate cancer cell lines. For example, inhibition of …
androgen-independent state. Evidence has been accumulating that interleukin-6 (IL-6) may
contribute to prostate cancer progression. Serum levels of IL-6 correlate with prostate tumor
burden and patient morbidity. The prostate tissue itself appears to be a source of IL-6 and its
receptor. Furthermore, experimental data suggest that IL-6 is an autocrine and paracrine
growth factor for androgen-independent prostate cancer cell lines. For example, inhibition of …
