Reactive oxygen and nitrogen species, generated by neutrophils and macrophages in
chronically inflamed tissues, readily damage DNA, producing a variety of potentially
genotoxic etheno base lesions; such inflammation-related DNA damage is now known to
contribute to carcinogenesis. Although the human alkyladenine DNA glycosylase (AAG) can
specifically bind DNA containing either 1, N 6-ethenoadenine (ϵA) lesions or 3, N 4-
ethenocytosine (ϵC) lesions, it can only excise ϵA lesions. AAG binds very tightly to DNA …