Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population

W Li, M Minohara, JJ Su, T Matsuoka… - Journal of …, 2007 - Elsevier
Persistent Helicobacter pylori (H. pylori) infection is a chronic inflammatory stimulus to hosts
with an inverse correlation to atopic disorders. In this study, a total of 105 consecutive
multiple sclerosis (MS) patients were divided into 52 opticospinal MS (OSMS) and 53
conventional MS (CMS), and their sera, along with those from 85 healthy controls (HC), were
examined by an enzyme-linked immunosorbent assay using antibodies against H. pylori. H.
pylori seropositivity was significantly lower in patients with CMS (22.6%) compared with HC …