[HTML][HTML] Fatty acid (FFA) transport in cardiomyocytes revealed by imaging unbound FFA is mediated by an FFA pump modulated by the CD36 protein
AN Carley, AM Kleinfeld - Journal of biological chemistry, 2011 - ASBMB
Free fatty acid (FFA) transport across the cardiomyocyte plasma membrane is essential to
proper cardiac function, but the role of membrane proteins and FFA metabolism in FFA
transport remains unclear. Metabolism is thought to maintain intracellular FFA at low levels,
providing the driving force for FFA transport, but intracellular FFA levels have not been
measured directly. We report the first measurements of the intracellular unbound FFA
concentrations (FFA i) in cardiomyocytes. The fluorescent indicator of FFA, ADIFAB …
proper cardiac function, but the role of membrane proteins and FFA metabolism in FFA
transport remains unclear. Metabolism is thought to maintain intracellular FFA at low levels,
providing the driving force for FFA transport, but intracellular FFA levels have not been
measured directly. We report the first measurements of the intracellular unbound FFA
concentrations (FFA i) in cardiomyocytes. The fluorescent indicator of FFA, ADIFAB …