Dietary fructose inhibits intestinal calcium absorption and induces vitamin D insufficiency in CKD
V Douard, A Asgerally, Y Sabbagh… - Journal of the …, 2010 - journals.lww.com
Renal disease leads to perturbations in calcium and phosphate homeostasis and vitamin D
metabolism. Dietary fructose aggravates chronic kidney disease (CKD), but whether it also
worsens CKD-induced derangements in calcium and phosphate homeostasis is unknown.
Here, we fed rats diets containing 60% glucose or fructose for 1 mo beginning 6 wk after 5/6
nephrectomy or sham operation. Nephrectomized rats had markedly greater kidney weight,
blood urea nitrogen, and serum levels of creatinine, phosphate, and calcium-phosphate …
metabolism. Dietary fructose aggravates chronic kidney disease (CKD), but whether it also
worsens CKD-induced derangements in calcium and phosphate homeostasis is unknown.
Here, we fed rats diets containing 60% glucose or fructose for 1 mo beginning 6 wk after 5/6
nephrectomy or sham operation. Nephrectomized rats had markedly greater kidney weight,
blood urea nitrogen, and serum levels of creatinine, phosphate, and calcium-phosphate …