Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: memory T cells make the difference
S Meller, AI Lauerma, FM Kopp, F Winterberg… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: As clinical and histological features of allergic and irritant contact dermatitis
share common characteristics, the differentiation between them in the preclinical and clinical
evaluations of chemicals remains difficult. OBJECTIVE: To identify the differences in the
underlying immunological mechanisms of chemical-induced allergic or irritant skin
responses. METHODS: We systematically studied the involvement of chemokines in both
diseases by quantitative real-time polymerase chain reaction in mice and humans. The …
share common characteristics, the differentiation between them in the preclinical and clinical
evaluations of chemicals remains difficult. OBJECTIVE: To identify the differences in the
underlying immunological mechanisms of chemical-induced allergic or irritant skin
responses. METHODS: We systematically studied the involvement of chemokines in both
diseases by quantitative real-time polymerase chain reaction in mice and humans. The …