[HTML][HTML] A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation
M Tatematsu, A Ishii, H Oshiumi, M Horiuchi… - Journal of biological …, 2010 - ASBMB
The Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 (TICAM-1, also called
TRIF) is a signaling adaptor for TLR3 and TLR4 that activates the transcription factors IRF-3,
NF-κB, and AP-1, leading to induction of type I interferon and cytokines. The N-terminal
region of TICAM-1 participates in IRF-3 activation, although the C-terminal region is involved
in NF-κB activation. However, the mechanism by which TICAM-1 is activated and transmits
signals is largely unknown. In this study, we identified Leu 194 as a critical amino acid for …
TRIF) is a signaling adaptor for TLR3 and TLR4 that activates the transcription factors IRF-3,
NF-κB, and AP-1, leading to induction of type I interferon and cytokines. The N-terminal
region of TICAM-1 participates in IRF-3 activation, although the C-terminal region is involved
in NF-κB activation. However, the mechanism by which TICAM-1 is activated and transmits
signals is largely unknown. In this study, we identified Leu 194 as a critical amino acid for …