[HTML][HTML] Mechanisms of the TRIF-induced interferon-stimulated response element and NF-κB activation and apoptosis pathways
KJ Han, X Su, LG Xu, LH Bin, J Zhang… - Journal of Biological …, 2004 - ASBMB
Toll-like receptor-3 is critically involved in host defense against viruses through induction of
type I interferons (IFNs). Recent studies suggest that a Toll/interleukin-1 receptor domain-
containing adapter protein (TRIF) and two protein kinases (TANK-binding kinase-1 (TBK1)
and IκB kinase (IKK)-ϵ) are critically involved in Toll-like receptor-3-mediated IFN-β
production through activation of IFN regulatory factor (IRF)-3 and IRF-7. In this study, we
demonstrate that TRIF interacts with both IRF-7 and IRF-3. In addition to TBK1 and IKKϵ, our …
type I interferons (IFNs). Recent studies suggest that a Toll/interleukin-1 receptor domain-
containing adapter protein (TRIF) and two protein kinases (TANK-binding kinase-1 (TBK1)
and IκB kinase (IKK)-ϵ) are critically involved in Toll-like receptor-3-mediated IFN-β
production through activation of IFN regulatory factor (IRF)-3 and IRF-7. In this study, we
demonstrate that TRIF interacts with both IRF-7 and IRF-3. In addition to TBK1 and IKKϵ, our …