[HTML][HTML] Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-κB and interferon regulatory factor-3 …
Toll-IL-1 receptor (TIR) domain-containing adaptor molecule-1 (TICAM-1, also named TIR
domain-containing adaptor-inducing interferon (IFN)-β or TRIF)) is a signaling adaptor of
Toll-like receptor (TLR) 3/4 that activates the transcription factors, interferon regulatory factor-
3 (IRF-3) and NF-κB leading to inducing IFN-β production. The mechanisms by which TICAM-
1 is activated by TLR3/4 to serve as a signaling platform are unknown. In this study, we show
that homo-oligomerization of TICAM-1 is critical for TICAM-1-mediated activation of NF-κB …
domain-containing adaptor-inducing interferon (IFN)-β or TRIF)) is a signaling adaptor of
Toll-like receptor (TLR) 3/4 that activates the transcription factors, interferon regulatory factor-
3 (IRF-3) and NF-κB leading to inducing IFN-β production. The mechanisms by which TICAM-
1 is activated by TLR3/4 to serve as a signaling platform are unknown. In this study, we show
that homo-oligomerization of TICAM-1 is critical for TICAM-1-mediated activation of NF-κB …