Patterning of the mammalian cochlea
R Cantos, LK Cole, D Acampora… - Proceedings of the …, 2000 - National Acad Sciences
Proceedings of the National Academy of Sciences, 2000•National Acad Sciences
The mammalian cochlea is sophisticated in its function and highly organized in its structure.
Although the anatomy of this sense organ has been well documented, the molecular
mechanisms underlying its development have remained elusive. Information generated from
mutant and knockout mice in recent years has increased our understanding of cochlear
development and physiology. This article discusses factors important for the development of
the inner ear and summarizes cochlear phenotypes of mutant and knockout mice …
Although the anatomy of this sense organ has been well documented, the molecular
mechanisms underlying its development have remained elusive. Information generated from
mutant and knockout mice in recent years has increased our understanding of cochlear
development and physiology. This article discusses factors important for the development of
the inner ear and summarizes cochlear phenotypes of mutant and knockout mice …
The mammalian cochlea is sophisticated in its function and highly organized in its structure. Although the anatomy of this sense organ has been well documented, the molecular mechanisms underlying its development have remained elusive. Information generated from mutant and knockout mice in recent years has increased our understanding of cochlear development and physiology. This article discusses factors important for the development of the inner ear and summarizes cochlear phenotypes of mutant and knockout mice, particularly Otx and Otx2. We also present data on gross development of the mouse cochlea.
National Acad Sciences