Persistence of influenza virus-specific antibody-secreting cells and B-cell memory after primary murine influenza virus infection
PD Jones, GL Ada - Cellular immunology, 1987 - Elsevier
Influenza virus-specific antibody-secreting cells (ASCs), enumerated using an ELISA-plaque
assay, were found in the lung and spleen up to 18 months after primary murine influenza
infection. The number of ASCs generated in stimulated lung and spleen cell cultures
increased 50-to 200-fold after influenza infection. Whereas the level of response did not
change in spleen cell cultures up to 18 months after infection, there was a gradual reduction
in ASCs in lung cell cultures obtained more than 6 months after infection, predominantly due …
assay, were found in the lung and spleen up to 18 months after primary murine influenza
infection. The number of ASCs generated in stimulated lung and spleen cell cultures
increased 50-to 200-fold after influenza infection. Whereas the level of response did not
change in spleen cell cultures up to 18 months after infection, there was a gradual reduction
in ASCs in lung cell cultures obtained more than 6 months after infection, predominantly due …