[HTML][HTML] Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2
SE Girardin, LH Travassos, M Hervé, D Blanot… - Journal of Biological …, 2003 - ASBMB
Nod1 and Nod2 are mammalian proteins implicated in the intracellular detection of
pathogen-associated molecular patterns. Recently, naturally occurring peptidoglycan (PG)
fragments were identified as the microbial motifs sensed by Nod1 and Nod2. Whereas Nod2
detects GlcNAc-MurNAc dipeptide (GM-Di), Nod1 senses a unique diaminopimelate-
containing GlcNAc-MurNAc tripeptide muropeptide (GM-Tri DAP) found mostly in Gram-
negative bacterial PGs. Because Nod1 and Nod2 detect similar yet distinct muropeptides …
pathogen-associated molecular patterns. Recently, naturally occurring peptidoglycan (PG)
fragments were identified as the microbial motifs sensed by Nod1 and Nod2. Whereas Nod2
detects GlcNAc-MurNAc dipeptide (GM-Di), Nod1 senses a unique diaminopimelate-
containing GlcNAc-MurNAc tripeptide muropeptide (GM-Tri DAP) found mostly in Gram-
negative bacterial PGs. Because Nod1 and Nod2 detect similar yet distinct muropeptides …
