Dysregulation of the mesolimbic dopamine system and reward in MCH−/− mice
P Pissios, L Frank, AR Kennedy, DR Porter… - Biological …, 2008 - Elsevier
BACKGROUND: The hypothalamic neuropeptide melanin-concentrating hormone (MCH)
plays a critical role in energy homeostasis. Abundant expression of the MCH receptor is
observed outside the hypothalamus, especially in the dorsal and the ventral striatum, raising
the possibility that MCH modulates the function of the midbrain dopamine neurons and
associated circuitry. METHODS: The MCH receptor 1 (MCHR1) expression was assessed by
in situ hybridization. Expression of dopamine transporter (DAT) and the dopamine D1 and …
plays a critical role in energy homeostasis. Abundant expression of the MCH receptor is
observed outside the hypothalamus, especially in the dorsal and the ventral striatum, raising
the possibility that MCH modulates the function of the midbrain dopamine neurons and
associated circuitry. METHODS: The MCH receptor 1 (MCHR1) expression was assessed by
in situ hybridization. Expression of dopamine transporter (DAT) and the dopamine D1 and …