[HTML][HTML] Proteomic analysis of protein expression and oxidative modification in R6/2 transgenic mice
M Perluigi, HF Poon, W Maragos, WM Pierce… - Molecular & Cellular …, 2005 - ASBMB
Huntington disease (HD) is a hereditary neurodegenerative disorder characterized by motor,
psychiatric, and cognitive symptoms. The genetic defect responsible for the onset of the
disease, expansion of CAG repeats in exon 1 of the gene that codes for huntingtin on
chromosome 4, has been unambiguously identified. On the other hand, the mechanisms by
which the mutation causes the disease are not completely understood yet. However, defects
in energy metabolism of affected cells may cause oxidative damage, which has been …
psychiatric, and cognitive symptoms. The genetic defect responsible for the onset of the
disease, expansion of CAG repeats in exon 1 of the gene that codes for huntingtin on
chromosome 4, has been unambiguously identified. On the other hand, the mechanisms by
which the mutation causes the disease are not completely understood yet. However, defects
in energy metabolism of affected cells may cause oxidative damage, which has been …