Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells
H Al-Hussaini, M Schneiders, P Lundh… - Experimental eye …, 2009 - Elsevier
Drusen are extra-cellular deposits that form between the retinal pigment epithelium (RPE)
and Bruch's membrane (BM). Numerous and/or confluent drusen are a significant risk factor
for age-related macular degeneration (AMD). Here, using whole mounted human RPE
preparation we show that RPE cell morphology changes in association with drusen. These
changes included an increase in cell size and distortion in the regularity of their distribution.
Further, although binucleation is relatively rare in human RPE, there was a marked increase …
and Bruch's membrane (BM). Numerous and/or confluent drusen are a significant risk factor
for age-related macular degeneration (AMD). Here, using whole mounted human RPE
preparation we show that RPE cell morphology changes in association with drusen. These
changes included an increase in cell size and distortion in the regularity of their distribution.
Further, although binucleation is relatively rare in human RPE, there was a marked increase …