[HTML][HTML] The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells
C Vives-Bauza, M Anand, AK Shirazi, J Magrane… - Journal of Biological …, 2008 - ASBMB
Accumulation of indigestible lipofuscin and decreased mitochondrial energy production are
characteristic age-related changes of post-mitotic retinal pigment epithelial (RPE) cells in the
human eye. To test whether these two forms of age-related impairment have interdependent
effects, we quantified the ATP-dependent phagocytic function of RPE cells loaded or not with
the lipofuscin component A2E and inhibiting or not mitochondrial ATP synthesis either
pharmacologically or genetically. We found that physiological levels of lysosomal A2E …
characteristic age-related changes of post-mitotic retinal pigment epithelial (RPE) cells in the
human eye. To test whether these two forms of age-related impairment have interdependent
effects, we quantified the ATP-dependent phagocytic function of RPE cells loaded or not with
the lipofuscin component A2E and inhibiting or not mitochondrial ATP synthesis either
pharmacologically or genetically. We found that physiological levels of lysosomal A2E …