The interacting pathways for prevention and repair of oxidative DNA damage
G Slupphaug, B Kavli, HE Krokan - Mutation Research/Fundamental and …, 2003 - Elsevier
Genomes are damaged by spontaneous decay, chemicals, radiation and replication errors.
DNA damage may cause mutations resulting in inheritable disease, cancer and ageing.
Oxidative stress from ionising radiation and oxidative metabolism causes base damage, as
well as strand breaks in DNA. Base damage is mostly indirect and caused by reactive
oxygen species (ROS) generated, eg O2−(superoxide radical), OH (hydroxyl radical) and
H2O2 (hydrogen peroxide). ROS also oxidise RNA, lipids, proteins and nucleotides. The first …
DNA damage may cause mutations resulting in inheritable disease, cancer and ageing.
Oxidative stress from ionising radiation and oxidative metabolism causes base damage, as
well as strand breaks in DNA. Base damage is mostly indirect and caused by reactive
oxygen species (ROS) generated, eg O2−(superoxide radical), OH (hydroxyl radical) and
H2O2 (hydrogen peroxide). ROS also oxidise RNA, lipids, proteins and nucleotides. The first …
