[HTML][HTML] The binding site in β2-glycoprotein I for ApoER2′ on platelets is located in domain V
M van Lummel, MTT Pennings, RHWM Derksen… - Journal of Biological …, 2005 - ASBMB
The antiphospholipid syndrome is caused by autoantibodies directed against β 2-
glycoprotein I (β 2 GPI). Dimerization of β 2 GPI results in an increased platelet deposition to
collagen. We found that apolipoprotein E receptor 2′(apoER2′), a member of the low
density lipoprotein receptor family, is involved in activation of platelets by dimeric β 2 GPI. To
identify which domain of dimeric β 2 GPI interacts with apoER2′, we have constructed
domain deletion mutants of dimeric β 2 GPI, lacking domain I (ΔI), II (ΔII), or V (ΔV), and a …
glycoprotein I (β 2 GPI). Dimerization of β 2 GPI results in an increased platelet deposition to
collagen. We found that apolipoprotein E receptor 2′(apoER2′), a member of the low
density lipoprotein receptor family, is involved in activation of platelets by dimeric β 2 GPI. To
identify which domain of dimeric β 2 GPI interacts with apoER2′, we have constructed
domain deletion mutants of dimeric β 2 GPI, lacking domain I (ΔI), II (ΔII), or V (ΔV), and a …
