Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells
KE Knudsen, KC Arden, WK Cavenee - Journal of Biological Chemistry, 1998 - ASBMB
Prostatic epithelial cells and most primary prostate tumors are dependent on androgen for
growth, but how androgen regulates cellular proliferation remains unsolved. Using poorly
understood mechanisms, recurrent tumor cells evade the androgen requirement. We utilized
androgen-dependent prostatic tumor cells to demonstrate that androgen exerts its effect on
the cell cycle by influencing specific aspects of G 1-S progression. Androgen depletion of
these cells results in early G 1 arrest, characterized by reduced cyclin-dependent kinase …
growth, but how androgen regulates cellular proliferation remains unsolved. Using poorly
understood mechanisms, recurrent tumor cells evade the androgen requirement. We utilized
androgen-dependent prostatic tumor cells to demonstrate that androgen exerts its effect on
the cell cycle by influencing specific aspects of G 1-S progression. Androgen depletion of
these cells results in early G 1 arrest, characterized by reduced cyclin-dependent kinase …
