[HTML][HTML] A phase I/II randomized open-label multicenter trial of efalizumab, a humanized anti-CD11a, anti-LFA-1 in renal transplantation
F Vincenti, R Mendez, M Pescovitz… - American journal of …, 2007 - Elsevier
Leukocyte function associated antigen-1 (LFA-1) has a multifaceted role in the immune
response, including adhesion and trafficking of leukocytes, stabilizing the immune synapse
of the MHC-TCR complex and providing costimulation signals. Monoclonal antibodies to the
CD11a chain of LFA-1 have been seen to result in effective immunosuppression in
experimental models. Efalizumab, a humanized IgG1 anti-CD11a, is approved for use in
psoriasis and may provide effective immunosuppression in organ transplantation. Thirty …
response, including adhesion and trafficking of leukocytes, stabilizing the immune synapse
of the MHC-TCR complex and providing costimulation signals. Monoclonal antibodies to the
CD11a chain of LFA-1 have been seen to result in effective immunosuppression in
experimental models. Efalizumab, a humanized IgG1 anti-CD11a, is approved for use in
psoriasis and may provide effective immunosuppression in organ transplantation. Thirty …
