[HTML][HTML] Geminin has dimerization, Cdt1-binding, and destruction domains that are required for biological activity
JM Benjamin, SJ Torke, B Demeler… - Journal of Biological …, 2004 - ASBMB
Geminin is an unstable regulatory protein that affects both cell division and cell
differentiation. Geminin inhibits a second round of DNA synthesis during S and G 2 phase by
binding the essential replication protein Cdt1. Geminin is also required for entry into mitosis,
either by preventing replication abnormalities or by down-regulating the checkpoint kinase
Chk1. Geminin overexpression during embryonic development induces ectopic neural
tissue, inhibits eye formation, and perturbs the segmental patterning of the embryo. In order …
differentiation. Geminin inhibits a second round of DNA synthesis during S and G 2 phase by
binding the essential replication protein Cdt1. Geminin is also required for entry into mitosis,
either by preventing replication abnormalities or by down-regulating the checkpoint kinase
Chk1. Geminin overexpression during embryonic development induces ectopic neural
tissue, inhibits eye formation, and perturbs the segmental patterning of the embryo. In order …
