Cytokine related therapies for autoimmune disease
TB Strom, M Koulmanda - Current opinion in immunology, 2008 - Elsevier
TB Strom, M Koulmanda
Current opinion in immunology, 2008•ElsevierIn short, manipulation of cytokine pathways shows promise as a mean to tilt the balance of
immunity toward tolerance. Effective and regulatory T cells vary in their response to a variety
of cytokines. In particular, the ability of certain cytokines, for example, IL-2, to provide vital
survival signals to regulatory cells and to trigger death of effector T cells or impede IL-15
driven expansion of memory cells has spurred several trials. The ability of IFNγ, IL-4, TNFα,
and lymphotoxin to exert selective effects upon crucial lymphocyte subset populations in …
immunity toward tolerance. Effective and regulatory T cells vary in their response to a variety
of cytokines. In particular, the ability of certain cytokines, for example, IL-2, to provide vital
survival signals to regulatory cells and to trigger death of effector T cells or impede IL-15
driven expansion of memory cells has spurred several trials. The ability of IFNγ, IL-4, TNFα,
and lymphotoxin to exert selective effects upon crucial lymphocyte subset populations in …
In short, manipulation of cytokine pathways shows promise as a mean to tilt the balance of immunity toward tolerance. Effective and regulatory T cells vary in their response to a variety of cytokines. In particular, the ability of certain cytokines, for example, IL-2, to provide vital survival signals to regulatory cells and to trigger death of effector T cells or impede IL-15 driven expansion of memory cells has spurred several trials. The ability of IFNγ, IL-4, TNFα, and lymphotoxin to exert selective effects upon crucial lymphocyte subset populations in vivo may also enable translation into potent therapies.
Elsevier