Expression profiling with progression of dystrophic change in dysferlin-deficient mice (SJL)
N Suzuki, M Aoki, Y Hinuma, T Takahashi… - Neuroscience …, 2005 - Elsevier
The SJL mouse is a model for human dysferlinopathy (limb-girdle muscular dystrophy type
2B and Miyoshi myopathy). We used cDNA microarrays to compare the expression profiles
of 10,012 genes in control and SJL quadriceps femoris muscles in order to find genes
involved in the degeneration and regeneration process and in dysferlin's functional network.
Many genes involved in the process of muscle regeneration are observed to be up-
regulated in SJL mice, including cardiac ankyrin repeated protein (CARP), Neuraminidase …
2B and Miyoshi myopathy). We used cDNA microarrays to compare the expression profiles
of 10,012 genes in control and SJL quadriceps femoris muscles in order to find genes
involved in the degeneration and regeneration process and in dysferlin's functional network.
Many genes involved in the process of muscle regeneration are observed to be up-
regulated in SJL mice, including cardiac ankyrin repeated protein (CARP), Neuraminidase …