[HTML][HTML] Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function
M Gaur, T Kamata, S Wang, B Moran, SJ Shattil… - Journal of Thrombosis …, 2006 - Elsevier
Background: The platelet fibrinogen receptor, a heterodimer consisting of integrin subunits α
IIb and β 3, is required for platelet aggregation, spreading, and hemostasis. Platelet agonists
such as thrombin and adenosine diphosphate (ADP) lead to the activation of α IIb β 3,
thereby enhancing its affinity and avidity for binding fibrinogen (inside‐out signaling).
Furthermore, fibrinogen binding to α IIb β 3 triggers cytoskeletal changes and granule
release (outside‐in signaling). Aim: Genetic approaches to characterize the molecular …
IIb and β 3, is required for platelet aggregation, spreading, and hemostasis. Platelet agonists
such as thrombin and adenosine diphosphate (ADP) lead to the activation of α IIb β 3,
thereby enhancing its affinity and avidity for binding fibrinogen (inside‐out signaling).
Furthermore, fibrinogen binding to α IIb β 3 triggers cytoskeletal changes and granule
release (outside‐in signaling). Aim: Genetic approaches to characterize the molecular …