The small GTP-binding protein Ras is pivotal in transmitting growth and differentiation
signals downstream of cell surface receptors. Many observations have indicated that Ras
transmits signals from cell surface receptors into multiple pathways via direct interaction with
different effectors in mammalian cells. We have identified a novel potential Ras effector or
target named Nore1. Nore1 has no significant sequence similarity to known mammalian
proteins and lacks an identifiable catalytic domain, but contains sequence motifs that predict …