Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis
MD Vos, CA Ellis, A Bell, MJ Birrer, GJ Clark - Journal of Biological …, 2000 - ASBMB
Although activated Ras proteins are usually associated with driving growth and
transformation, they may also induce senescence, apoptosis, and terminal differentiation.
The subversion of these anti-neoplastic effects during Ras-dependent tumor development
may be as important as the acquisition of the pro-neoplastic effects. None of the currently
identified potential Ras effector proteins can satisfactorily explain the apoptotic action of
Ras. Consequently, we have sought to identify novel Ras effectors that may be responsible …
transformation, they may also induce senescence, apoptosis, and terminal differentiation.
The subversion of these anti-neoplastic effects during Ras-dependent tumor development
may be as important as the acquisition of the pro-neoplastic effects. None of the currently
identified potential Ras effector proteins can satisfactorily explain the apoptotic action of
Ras. Consequently, we have sought to identify novel Ras effectors that may be responsible …
