High-and low-calcium-dependent mechanisms of mitochondrial calcium signalling
A Spät, G Szanda, G Csordás, G Hajnóczky - Cell calcium, 2008 - Elsevier
The Ca2+ coupling between endoplasmic reticulum (ER) and mitochondria is central to
multiple cell survival and cell death mechanisms. Cytoplasmic [Ca2+]([Ca2+] c) spikes and
oscillations produced by ER Ca2+ release are effectively delivered to the mitochondria.
Propagation of [Ca2+] c signals to the mitochondria requires the passage of Ca2+ across
three membranes, namely the ER membrane, the outer mitochondrial membrane (OMM)
and the inner mitochondrial membrane (IMM). Strategic positioning of the mitochondria by …
multiple cell survival and cell death mechanisms. Cytoplasmic [Ca2+]([Ca2+] c) spikes and
oscillations produced by ER Ca2+ release are effectively delivered to the mitochondria.
Propagation of [Ca2+] c signals to the mitochondria requires the passage of Ca2+ across
three membranes, namely the ER membrane, the outer mitochondrial membrane (OMM)
and the inner mitochondrial membrane (IMM). Strategic positioning of the mitochondria by …
