Molecular biology and chemistry of the alternative pathway of complement
HJ Müller-Eberhard, RD Schreiber - Advances in immunology, 1980 - Elsevier
Publisher Summary This chapter presents the proteins of the alternative pathway and their
special properties as enzymes, enzyme substrates, and regulators. The participation with the
classical pathway components, C5–C9, in membrane attack is considered. The surprising
discovery of the activation of the alternative pathway by many systems other than antibody is
emphasized along with the key role played by C3 and its component parts. The alternative
pathway of complement activation is closely linked to natural resistance to infections. The …
special properties as enzymes, enzyme substrates, and regulators. The participation with the
classical pathway components, C5–C9, in membrane attack is considered. The surprising
discovery of the activation of the alternative pathway by many systems other than antibody is
emphasized along with the key role played by C3 and its component parts. The alternative
pathway of complement activation is closely linked to natural resistance to infections. The …