Myocardial function depends on adenosine triphosphate (ATP) supplied by oxidation of
several substrates. In the adult heart, this energy is obtained primarily from fatty acid
oxidation through oxidative phosphorylation. However, the energy source may change
depending on several factors such as substrate availability, energy demands, oxygen
supply, and metabolic condition of the individual. Surprisingly, the role of energy metabolism
in development of cardiac diseases has not been extensively studied. For instance …