ALOHOMORA: a tool for linkage analysis using 10K SNP array data
F Rüschendorf, P Nürnberg - Bioinformatics, 2005 - academic.oup.com
F Rüschendorf, P Nürnberg
Bioinformatics, 2005•academic.oup.comALOHOMORA is a software tool designed to facilitate genome-wide linkage studies
performed with high-density single nucleotide polymorphism (SNP) marker panels such as
the Affymetrix GeneChip® Human Mapping 10K Array. Genotype data are converted into
appropriate formats for a number of common linkage programs and subjected to standard
quality control routines before linkage runs are started. ALOHOMORA is written in Perl and
may be used to perform state-of-the-art linkage scans in small and large families with any …
performed with high-density single nucleotide polymorphism (SNP) marker panels such as
the Affymetrix GeneChip® Human Mapping 10K Array. Genotype data are converted into
appropriate formats for a number of common linkage programs and subjected to standard
quality control routines before linkage runs are started. ALOHOMORA is written in Perl and
may be used to perform state-of-the-art linkage scans in small and large families with any …
Abstract
Summary: ALOHOMORA is a software tool designed to facilitate genome-wide linkage studies performed with high-density single nucleotide polymorphism (SNP) marker panels such as the Affymetrix GeneChip® Human Mapping 10K Array. Genotype data are converted into appropriate formats for a number of common linkage programs and subjected to standard quality control routines before linkage runs are started. ALOHOMORA is written in Perl and may be used to perform state-of-the-art linkage scans in small and large families with any genetic model. Options for using different genetic maps or ethnicity-specific allele frequencies are implemented. Graphic outputs of whole-genome multipoint LOD score values are provided for the entire dataset as well as for individual families.
Availability: ALOHOMORA is available free of charge for non-commercial research institutions. For more details, see http://gmc.mdc-berlin.de/alohomora/
Contact: fruesch@mdc-berlin.de
Oxford University Press