Blood coagulation involves a series of enzymatic protein complexes that assemble on the
surface of anionic phospholipid. To investigate whether apolipoproteins affect coagulation
reactions, they were included during the preparation of anionic phospholipid vesicles using
a detergent solubilization-dialysis method. Apolipoprotein components of high density
lipoproteins, especially apolipoprotein AI, had a pronounced anticoagulant effect. The
anionic phospholipids lost their procoagulant effect when the vesicle preparation method …