[HTML][HTML] Post-translational modifications in proteins involved in blood coagulation
K Hansson, J Stenflo - Journal of Thrombosis and Haemostasis, 2005 - Elsevier
Blood coagulation and its anticoagulant counterpart, the protein C (PC) system, proceed via
the formation of cell-associated macromolecular enzyme complexes that interact in a
precisely regulated manner. In the final step of coagulation thrombin is generated, which
cleaves soluble fibrinogen to form the insoluble fibrin monomers that constitute the structural
foundation of a blood clot [1, 2]. Post-translational protein modifications play pivotal roles in
both blood coagulation and the PC anticoagulant system.The relatively high concentration of …
the formation of cell-associated macromolecular enzyme complexes that interact in a
precisely regulated manner. In the final step of coagulation thrombin is generated, which
cleaves soluble fibrinogen to form the insoluble fibrin monomers that constitute the structural
foundation of a blood clot [1, 2]. Post-translational protein modifications play pivotal roles in
both blood coagulation and the PC anticoagulant system.The relatively high concentration of …