[HTML][HTML] Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin
PP Zhu, A Patterson, B Lavoie, J Stadler… - Journal of Biological …, 2003 - ASBMB
Hereditary spastic paraplegias comprise a group of clinically heterogeneous syndromes
characterized by lower extremity spasticity and weakness, with distal axonal degeneration in
the long ascending and descending tracts of the spinal cord. The early onset hereditary
spastic paraplegia SPG3A is caused by mutations in the atlastin/human guanylate-binding
protein-3 gene (renamed here atlastin-1), which codes for a 64-kDa member of the
dynamin/Mx/guanylate-binding protein superfamily of large GTPases. The atlastin-1 protein …
characterized by lower extremity spasticity and weakness, with distal axonal degeneration in
the long ascending and descending tracts of the spinal cord. The early onset hereditary
spastic paraplegia SPG3A is caused by mutations in the atlastin/human guanylate-binding
protein-3 gene (renamed here atlastin-1), which codes for a 64-kDa member of the
dynamin/Mx/guanylate-binding protein superfamily of large GTPases. The atlastin-1 protein …