Posttranscriptional orchestration of an anti-apoptotic program by HuR
Cell cycle, 2007•Taylor & Francis
The RNA-binding protein HuR can stabilize and/or regulate the translation of target mRNAs,
thereby affecting the cellular responses to immune, proliferative, and damaging agents.
Here, we discuss emerging evidence that HuR elicits a broad anti-apoptotic function through
its influence on the expression of multiple target mRNAs. HuR was previously shown to bind
to the mRNA encoding the apoptosome inhibitor prothymosin α (ProTα) and enhanced its
translation and cytoplasmic abundance. More recently, HuR was shown to increase the …
thereby affecting the cellular responses to immune, proliferative, and damaging agents.
Here, we discuss emerging evidence that HuR elicits a broad anti-apoptotic function through
its influence on the expression of multiple target mRNAs. HuR was previously shown to bind
to the mRNA encoding the apoptosome inhibitor prothymosin α (ProTα) and enhanced its
translation and cytoplasmic abundance. More recently, HuR was shown to increase the …
The RNA-binding protein HuR can stabilize and/or regulate the translation of target mRNAs, thereby affecting the cellular responses to immune, proliferative, and damaging agents. Here, we discuss emerging evidence that HuR elicits a broad anti-apoptotic function through its influence on the expression of multiple target mRNAs. HuR was previously shown to bind to the mRNA encoding the apoptosome inhibitor prothymosin α (ProTα) and enhanced its translation and cytoplasmic abundance. More recently, HuR was shown to increase the stability of a target mRNA encoding the pro-survival deacetylase SIRT1. The discovery that HuR likewise binds to and promotes the expression of mRNAs encoding Bcl-2 and Mcl-1, two major anti-apoptotic effectors, strongly supports HuR’s role as a key upstream coordinator of a constitutive pro-survival program.
Taylor & Francis Online