[HTML][HTML] TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival
Insulin-like growth factor-I (IGF-I) receptors and insulin receptors belong to the same
subfamily of receptor tyrosine kinases and share a similar set of intracellular signaling
pathways, despite their distinct biological actions. In the present study, we evaluated T cell
death-associated gene 51 (TDAG51), which we previously identified by cDNA microarray
analysis as a gene specifically induced by IGF-I. We characterized the signaling pathways
by which IGF-I induces TDAG51 gene expression and the functional role of TDAG51 in IGF-I …
subfamily of receptor tyrosine kinases and share a similar set of intracellular signaling
pathways, despite their distinct biological actions. In the present study, we evaluated T cell
death-associated gene 51 (TDAG51), which we previously identified by cDNA microarray
analysis as a gene specifically induced by IGF-I. We characterized the signaling pathways
by which IGF-I induces TDAG51 gene expression and the functional role of TDAG51 in IGF-I …