Bone marrow transplantation symposium: bone marrow transplantation for immunodeficiency diseases
RA Good - The American journal of the medical sciences, 1987 - Elsevier
Allogeneic bone marrow transplantation (BMT) was applied in 1968 to treat severe
combined immunodeficiency disease (SCID). Almost simultaneously, marrow from an MHC-
matched donor corrected the immunological deficiency of a patient with Wiscott-Aldrich
Syndrome (WAS). In the first successful treatment of X-linked SCID the match was imperfect
and, although SCID was cured, a graft vs. host reaction caused pancytopenia. A second
BMT from the same donor successfully treated a complicating aplastic anemia …
combined immunodeficiency disease (SCID). Almost simultaneously, marrow from an MHC-
matched donor corrected the immunological deficiency of a patient with Wiscott-Aldrich
Syndrome (WAS). In the first successful treatment of X-linked SCID the match was imperfect
and, although SCID was cured, a graft vs. host reaction caused pancytopenia. A second
BMT from the same donor successfully treated a complicating aplastic anemia …
