Increased expression of osteopontin in the heart tissue of Lewis rats with experimental autoimmune myocarditis

T Shin, M Ahn, H Kim, HM Kim… - Journal of veterinary …, 2006 - jstage.jst.go.jp
T Shin, M Ahn, H Kim, HM Kim, Y Matsumoto
Journal of veterinary medical science, 2006jstage.jst.go.jp
The expression of osteopontin (OPN) in the hearts of rats with experimental autoimmune
myocarditis (EAM) was evaluated. Western blot analysis showed that OPN was significantly
increased in the hearts with EAM compared with those of complete Freund's adjuvant (CFA)
immunized control. Immunohistochemically, OPN was weakly expressed in the
cardiomyocytes in the heart with normal and CFA immunized controls. In EAM lesions, OPN
was intensely immunostained in some inflammatory cells, mainly ED1 positive …
Abstract
The expression of osteopontin (OPN) in the hearts of rats with experimental autoimmune myocarditis (EAM) was evaluated. Western blot analysis showed that OPN was significantly increased in the hearts with EAM compared with those of complete Freund’s adjuvant (CFA) immunized control. Immunohistochemically, OPN was weakly expressed in the cardiomyocytes in the heart with normal and CFA immunized controls. In EAM lesions, OPN was intensely immunostained in some inflammatory cells, mainly ED1 positive macrophages. These findings suggest that OPN is significantly increased in EAM lesions and that OPN mediates the inflammatory process in the course of rat EAM model.
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